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Archived: This report is greater than 3 years old. Findings may be used for research purposes, but should not be considered current.
This report is from AHRQ's series on Future Research Needs Projects.
Excerpt
Uncertainties Prompting Systematic Review
Chronic venous leg ulcers affect between 500,000 and 2 million persons annually, and over 50 percent of leg ulcers in the United States are classified as venous ulcers. They are caused by elevated venous pressure, turbulent venous flow, and inadequate venous return that can be due to occlusion or reflux in the venous system. The Johns Hopkins University Evidence-based Practice Center performed a systematic review to determine the effectiveness and safety of advanced wound dressings, systemic antibiotics, and surgical interventions relative to either compression systems or each other among patients with chronic venous leg ulcers. We defined chronic venous leg ulcers as active, noninfected ulcers present for 6 weeks or more with evidence of pre-existing venous disease. An analytic framework was used in the systematic review to describe research gaps. Standard therapy includes aggressive compression with debridement, which heals 50 to 60 percent of venous leg ulcers. Widely used add-on interventions include wound dressings with active components ("advanced wound dressings"), local or systemic antimicrobials, and venous surgery.The comparative effectiveness and safety of these advanced wound dressings, antimicrobials and surgical procedures is unclear.
Purpose of Future Research Needs Report
We sought to identify the evidence gaps in the systematic review, to engage a representative group of stakeholders in prioritizing the gaps, and to develop future research needs questions regarding the high-priority gaps, with some discussion of appropriate study design taking into consideration the pertinent populations, interventions, comparisons, outcome measures, timing, and setting (PICOTS).
