This report is available in PDF (688 kB) only. People using assistive technology may not be able to fully access information in these files. For additional assistance, please contact us.

Archived: This report is greater than 3 years old. Findings may be used for research purposes, but should not be considered current.

Structured Abstract

Background

The United States devotes significant resources to health care, yet quality is often lacking. In 2004, the Agency for Healthcare Research and Quality launched a collection of evidence reports on quality improvement (QI) opportunities and strategies related to chronic conditions, practice areas, and cross-cutting priorities. This new Closing the Quality Gap series expands the topics examined and marshals the knowledge of eight Evidence-based Practice Centers (EPCs) to synthesize lessons learned and to advance the state of QI science.

Methods

Each EPC conducted a systematic review of the peer-reviewed literature. Topic search strategies are available in the individual topic reports. This methods report relies on the final topic reports to highlight common lessons, identify implications for future systematic reviews of complex QI topics, and recommend next steps to advance the QI field.

Results

The series collectively assessed the evidence across quality levers and various populations, interventions, outcomes, settings, and contexts. Various approaches were taken to analyze the evidence in meaningful ways for key audiences. The challenges across reports informed approaches for future reviews, including use of logic models, approaches to defining and searching for complex health care interventions, assessment of individual study quality and strength of evidence, meaningful synthesis, and methods for synthesis. Directions for future QI research include the role of systematic review to advance the field, consistent measurement, consistent and complete reporting, a focus on health, understanding of context, and development of a common lexicon for QI intervention.

Conclusions

In their innovative review of these complex topics, EPCs faced several common challenges, including difficulty in synthesizing the evidence due to heterogeneity in choice of outcomes measures; limited ability to draw conclusions due to weaknesses in study design and incomplete reporting; and difficulty applying traditional systematic review methods to the multifaceted, context-dependent, systems-level interventions typical of the QI field. Future research will be strengthened by consistent use of a core set of outcomes measures, more robust study designs, more complete reporting of intervention characteristics and contextual factors, and development of additional systematic review methods specific to the QI field.